As with other defending drills, the defender needs to be ready to adjust to each change of direction the attacker makes and not over commit trying to stop a run.
Since attackers are able to move in all directions, it is important that defenders can move in all directions as well.
Position 4 cones in a square, roughly 12m a side. Inside the square, position a cone roughly 0.75m diagonally away from one outer cone. In the opposite corner, position another inner cone roughly 2.5m diagonally away from outer cone. In the other two corners, position cones roughly 1.5m diagonally away from outer cone. All these distances can be adjusted to increase or decrease the difficulty for the defender.
Attacker > Defender